STUDI PENGGUNAAN ANTIHIPERTENSI GOLONGAN CALCIUM CHANNEL BLOCKER (CCB) PADA PASIEN CHRONIC KIDNEY DISEASE (CKD) (Penelitian dilakukan di RSUD dr Iskak Tulungagung)

Background : Chronic Kidney Disease is defined as structural or functional abnormalities of the kidneys that occur for more than 3 months with a glomerular filtration rate (GFR) < 60 mL/min/1.73 m2 and a urine creatinine ratio (uACR) of more than 30 mg per day. The main clinical manifestations are symptoms of uremic syndrome such as lethargy, anorexia, nocturia, excessive fluid volume, peripheral neuropathy, uremic frost, and pericarditis, seizures, even coma. Management of CKD can be given one class of antihypertensive Calcium Channel Blocker aims to lower blood pressure with the mechanism of action of blocking the movement of calcium in muscle cells which causes vasodilation in blood vessels.
Objective : To determine the pattern of use Calcium Channel Blocker includes, type, dosage, combination, route amd duration in Chronic Kidney Disease patients at dr. Iskak Tulungagung.
Method : Retrospective observation in Chronic Kidney disease patients at the Regional General Hospital dr. Iskak Tulungagung Period 1 July – 31 December 2023
Result and Conclusion : Health medical record samples that met the inclusion criteria were 60 patients. Chronic Kidney Disease occurs mostly in male patients as many as 35 patients (58%) and 25 female patients (42%). Chronic Kidney Disease patients occur mostly at the age of 40-59 years as many as 39 patients (65%). The pattern of using a combination of 2 drugs was 34 patients (38%), a combination of 3 drugs was 34 patients (38%), a combination of 4 was 15 patients (17%). The most common use of a combination of 2 antihypertensives was Nifedipine (1x30 mg) po + Furosemide (3x40 mg) iv as many as 6 patients (16%). The most common combination of 3 antihypertensives was Amlodipine (1x10 mg) po + Furosemide (3x40 mg) iv + Valsartan (1x160 mg) po as many as 9 patients (26. Switch usage there are 41 patterns.