PREDIKSI INTERAKSI SENYAWA METABOLIT SEKUNDER TANAMAN BELUNTAS (Pluchea indica) TERHADAP HMGCoA REDUCTASE SECARA IN SILICO

Background: Hyperlipidemia is a condition of abnormal lipid levels in the blood. Pluchea indica plants has not been widely used as a traditional herbal treatment to treat hyperlipidemia. Also, until now there has been no research on the interaction of secondary metabolites of Pluchea indica plants by In silico.
Objective: To Predict the profile of Bioavailability, Affinity and Interaction of secondary metabolites of Pluchea indica plants against HMG-CoA Reductase by in silico
Metode: Using the SwissADME web server with the BOILED-Egg method and
use Druglikeness parameters to predict the bioavailability profile, as well as
performing Molecular Docking using Autodock software to predict the affinity
and interaction of secondary metabolite compounds in review with the Protein
Plus web server.
Result and conclusions: Of the 122 secondary metabolite compounds, 51
compounds are predicted to have a good oral bioavailability profile, indicated by
high GI Absorptions. Of the 51 test compounds, there is one compound that is
predicted to have potential affinity as an antihyperlipidemia and is predicted to
have an interaction with HMG-CoA Reductase similar to antihyperlipidemia
drugs of the statin group.