UJI AKTIVITAS ANTIJAMUR EKSTRAK N-HEKSAN DAUN MAHONI (Swietenia mahagoni L.) DENGAN KONSENTRASI 5%, 25%, 50% TERHADAP PERTUMBUHAN JAMUR Candida albicans

Background: Candidiasis is one of the most common fungal infections in Indonesia and is caused by Candida sp. Candidiasis can usually occur on the skin, hair and nails. This disease has the potential to affect men and women in all age groups around the world. Candidiasis is a frequent infectious problem in 20-25% of the world's population. It is estimated that about 25,000 cases of candidiasis appear every year (Rizqoh et al., 2022). Candida albicans is the most common cause of candidiasis and has represented an average of 66% of all Candida sp. species found worldwide. According to some epidemiological studies, Candida albicans species are responsible for 56% of candidiasis cases in Asia (Puspitasari et al., 2019).
Objective: To determine the antifungal potential of the n-hexane extract of mahogany leaves (Swietenia mahagoni L.) against Candida albicans which can be indicated by the formation of the diameter of the inhibition zone around the disc paper.
Methods: Experimental research with disc diffusion method. Antifungal activity testing of n-hexane extract of mahogany leaves (Swietenia mahagoni L.) will be compared with nystatin 50µL/disk. Data analysis was carried out descriptively and statistical tests.
Result and Conclusions: The n-Hexan extract of mahogany leaves (Swietenia mahagoni L.) has antifungal properties that can prevent the growth of Candida albicans. At a concentration of 5% test solution, the average inhibition zone was obtained at 6.51 ± 0.50 mm. At a concentration of 25%, the average diameter of the inhibition zone was slightly larger, namely 6.86 ± 0.53 mm. And the highest concentration of 50% showed the greatest antifungal activity, as evidenced by the average diameter of the inhibition zone of 7.04 ± 0.97 mm. Based on the results of statistical tests showed that there was a difference in the diameter of the inhibition zone (p<0.05) against Nystatin 50µg/disk in each treatment. Concentrations of 5%, 25%, and 50% had no significant difference because (p>0.05).