PENGARUH PEMBERIAN JAMU SARI RAPET TERHADAP HISTOLOGI ORGAN GINJAL DAN HATI TIKUS (Rattus novergius) SECARA IN VIVO SEBAGAI SUMBER BELAJAR

Sari rapet herbal medicine is one of the herbal medicines that has been frequently consumed by the Madurese people, especially Sumenep Regency, for generations. Consuming sari rapet herbal medicine aims to tighten female muscles and reduce vaginal discharge, however comsumtion of rapet sari herbal medicine has not yet gone through pre-clinical trials. This study aims to determine the effect of sari rapet essence herbal medicine on the histology of the kidney and liver organs of rats (Rattus novergicus). This type of research is True Experiment Research with a post-test-only control group design method. The samples used were female rat divided into four groups with different treatments, namely 0 g/200gBW, 0,54 g/200gBW, 1,08 g/200gBW, and 1,62 g/200gBW for 28 days a day. Histological changes data will be analyzed using the Shapiro-Wilk test and One-Way ANOVA. The research results showed that the highest damage was in group 3 (1.62 g/200gBW). The conclusion shows significant differences in kidney degeneration organ damage and inflammatory cell infiltration. There are significant differences in bridging necrosis damage, degeneration focal necrosis, and inflammatory cell infiltration in the liver. The results of this research can be used as a learning resource for high school biology in class.