STUDI PENGGUNAAN HISTAMINE-2 RECEPTORS ANTAGONIST (H2RA) PADA PASIEN GERD (Penelitian dilakukan di Instalasi Rawat Inap Rumah Sakit Umum Universitas Muhammadiyah Malang)

Background: Gastroesophageal Reflux Disease (GERD) is a gastrointestinal disorder with an increasing prevalence. The main pharmacological therapies are Proton Pump Inhibitors (PPIs) and Histamine-2 Receptors Antagonists (H2RA), where H2RA is still widely used in acute conditions in hospitals.
Objective: To determine the pattern of use of H2RA in GERD patients in the Inpatient Installation of the University of Muhammadiyah Malang Hospital.
Methods: A retrospective observational study with a descriptive approach using medical record data of GERD patients for the period January–December 2024.
Results and Conclusions: Of the 32 GERD patients, 18 patients received H2RA therapy, all in the form of ranitidine (1x50 mg i.v). The majority of patients were female (83%) with the highest age of 26–35 years. Therapy patterns included monotherapy (28%), a combination of two drugs (48%), and three drugs (24%), with the most duration of use being 0–2 days (72%). Most were treated <5 days (95%), discharged in improved condition (95%), and frequently received additional antiemetics (54%). In general, the use of H2RA at the University of Muhammadiyah Malang Hospital is rational, short-term effective, and supports clinical improvement.