PENGARUH SELADA (Lactuca sativa) TERHADAP PENURUNAN TINGKAT INSOMNIA DENGAN PENDEKATAN IN SILICO

Insomnia is a sleep disorder characterized by difficulty initiating and maintaining sleep, frequent awakenings, and feeling unrefreshed upon waking, significantly impacting quality of life. Conventional insomnia medications often have limited efficacy and side effects, such as excessive sedation and gastrointestinal disturbances. Lettuce (*Lactuca sativa*), a nutrient-rich natural substance, contains bioactive compounds like sesquiterpene lactones with known sedative effects, offering potential for improving sleep quality. This study aimed to evaluate the potential of active compounds in lettuce against GABA type A receptors using molecular docking with the AutoDock application. The binding energies of compounds such as Gibberellin A5, Gibberellin A53, Lactucopicrin, Crepidiaside B, 15-p-Hydroxyphenylacetyl-lactucin-8-sulfate, and Notoserolide A ranged from -8.69 to -10.02 kcal/mol, compared to alprazolam's -8.69 kcal/mol, indicating comparable or superior potential as insomnia-reducing agents. These findings suggest that active compounds in lettuce may serve as promising natural alternatives for managing insomnia.