AKTIVITAS ANTIBAKTERI ACNE PATCH MINYAK ATSIRI DAUN SIRIH (Piper betle L.) TERHADAP Propionibacterium acne

Background : Acne or acne vulgaris is a skin disease caused by excessive bacterial
colonization such as Propionibacterium acnes (P.acnes) bacteria. Betel leaf essential
oil contains bethepenol compound, which has antibacterial activity. Then
formulated into an acne patch preparation. Acne patch is an innovative preparation
to cover acne infection so that it does not spread and can avoid dust and air pollution
when outdoors.
Objective : This study was conducted to determine the effect of different
concentrations of PVA base on the inhibition zone of P. acne bacterial growth by
the well diffusion method, and to determine the optimal concentration of PVA base
in betel leaf essential oil patch preparation that has the highest antibacterial activity.
Method : This study tested the antibacterial activity of acne patch preparations with
different PVA bases with concentrations of 5%, 6%, and 7% using the well diffusion
method to determine the diameter of the inhibition zone produced from acne patch
preparations against Propionibacterium acnes bacteria, and analyzed using the One
Way-Anova statistical test SPSS 29.0.
Result and Conclusions : From the results of the study it was concluded that using
the wells diffusion method, acne patch preparations with PVA concentrations of
5%, 6% and 7% had antibacterial activity with inhibition zones against
Propionibacterium acne bacteria of 6,30 ± 1,11 mm ; 7,59 ± 1,11 mm ; 11,07 ± 1,08
mm. From the results of this study, it can be concluded that the difference in PVA
concentration in acne patch preparations does affect the inhibition of
Propionibacterium acne bacteria