STUDI PENGGUNAAN OBAT INOTROPIK PADA PASIEN GAGAL JANTUNG DI RSUD DR. MOHAMAD SOEWANDHIE SURABAYA

Background: Heart failure is a complex clinical syndrome that may arise from impaired myocardial function, both systolic and diastolic, as well as abnormalities of the cardiac valves or pericardium. Inotropics are pharmacological agents that enhance the interaction between calcium and contractile proteins in cardiac muscle, thereby increasing the strength of myocardial contraction and improving cardiac output and organ perfusion.
Objective: To describe the pattern of inotropic use in heart failure therapy, including dosage, type, frequency, route, duration, and administration pattern at Dr. Mohamad Soewandhie General Hospital, Surabaya.
Methods: Data collection was conducted using an observational and descriptive approach with retrospective data to characterize the use of inotropics in heart failure patients at Dr. Mohamad Soewandhie General Hospital during the period of February 2025 to August 2025.
Results and Conclusion: A total of 65 single inotropic patterns (63%), 17 two-drug combinations (16%), 1 three-drug combinations (1%), and 21 switch patterns (20%) were identified. The most common single pattern was digoxin (1×0.25 mg) orally, used in 36 patients (55%). The most frequent two-drug combination was digoxin (1×0.25 mg) IV + digoxin (1×0.25 mg) PO in 9 patients (52%). Three-drug combinations included amiodarone (300 mg) infusion + digoxin (1×0.25 mg) IV + digoxin (1×0.25 mg) PO found in 1 patient (100%). Switch patterns accounted for 21 regimens (20%).