Studi Penggunaan Antiplatelet pada Pasien Gagal Jantung di RSI Aisyiyah Malang

Background: Heart failure is a progressive clinical syndrome caused by systolic, diastolic, or both dysfunctions that impair the ventricles’ ability to pump blood. Patients with heart failure are prone to thrombosis due to hemodynamic disturbances, activation of the coagulation system, increased systemic inflammation, and endothelial dysfunction that promotes platelet adhesion and thrombus formation. Antiplatelet agents are used to prevent other cardiovascular events caused by atherosclerosis, such as heart failure and stroke.
Objective: Understand the pattern of antiplatelet use in heart failure patients, including type, dosage, frequency, route of administration, and duration of use at RSI Aisyiyah Malang.
Methods: Observational and descriptive study with retrospective data collection to describe antiplatelet usage patterns.
Results and Conclusion: A total of 45 single-use patterns (52%) and 35 dual-combination patterns (41%) were found. The most common single-use pattern was acetosal (1x80 mg) orally, in 26 cases (58%). The most frequent dual-combination pattern was acetosal (1x80 mg) orally + clopidogrel (1x75 mg) orally, used in 30 patients (86%). There were 6 switch patterns observed.