Studi Penggunaan Obat Angiotensin Converting Enzyme-Inhibitor pada Pasien Gagal Jantung (Penelitian Dilakukan di RSI Aisyiyah Malang)

Background : In 2019, more than 17,9 million people worldwide died from cardiovascular disease. Heart failure is a medical condition where the body lacks oxygen supply due to the heart being unable to function optimally. The ACE-Inhibitor group as an antihypertensive and anti-remodeling therapy.
Objective : This study aim to determine the pattern of ACE-Inhibitor use, including dosage, type, combination, switch, route, time interval, and duration of administration in heart failure patients at RSI Aisyiyah.
Method : This research is observational or non-experimental, namely a retrospective study with a time limited sampling method in 64 patients with heart failure from March to December 2024.
Result and Conclusion : ACE-Inhibitors are not given singly but in combination 2, combination 3, and combination 4. The most common pattern of use of combination 2 is Imidapril HCl (1x5 mg) + Bisoprolol (1x2,5 mg) which is 4 patients (31%), combination 3 Ramipril (1x5 mg) + Bisoprolol (1x2,5 mg) + Spironolactone (1x25 mg) 16 patients (40%), and combination 4 Imidapril HCl (1x10 mg) + Bisoprolol (1x,5 mg) + Spironolactone (1x25 mg) + Amlodipine (1x5 mg) 2 patients (20%). There are a total of 20 switch patterns.