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Acrylamide in Robusta Coffee on Blood Pressure, Urine Production and Renal Histopathological Change in White Male Rats

Lestari, Dian Yuliartha and Isbandiyah, Isbandiyah and Safithri, Fathiyah and Marcianto, Alfaries Radea and Rayyan, Rayyan (2017) Acrylamide in Robusta Coffee on Blood Pressure, Urine Production and Renal Histopathological Change in White Male Rats. In: Proceedings of the Health Science International Conference (HSIC 2017). Advances in Health Sciences Research . Atlantis Press, pp. 247-253. ISBN 978-94-6252-413-2

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Abstract

Background: Coffee is one of the popular drinks whole the world. Coffee’s contents are grouped into antioxidant (caffeine) and carcinogenic (acrylamide) agents. The mechanisms both of antioxidant and carcinogenic are contradicted in resulting the depiction of blood pressure, urine production and renal histopathology either protecting or damaging. Objective: To know the effect of Robusta coffee (Coffea canephora var. Robusta) towards blood pressure, urine production and change in renal histopatholgy on white male rats. Method: True Experimental, Post Test Only Control Group Design. Steeping Coffee with certain doses 0,36ml/day; 0,72ml/day; 1,44ml/day and 2,16ml/day were given orally for 28 days. The data analyzed by One Way ANOVA, Tukey, correlation, and regression. Result: The Steeping of Robusta coffee was able to causing an alterations of renal histopathology which characterized by tubular tyroidisasi (p=0,002) with optimal doses was 1,14 ml. The correlation values (0,774) showing strong correlation, whereas regression test influenced in the amount of 57,6%. Steeping coffee could increase blood pressure and urine output significantly (p=0,000) with optimal dose was 2,16ml/day. Each correlation value was 0819 and 0859 that showed a significant correlation, each regression test showed the influence of 67% and 92.1%. Conclusion: The Steeping of Robusta coffee increased the alterations of renal histopathology were characterized by tubular tyroidisasi, could increase blood preesure and urine output in white male rats.

Item Type: Book Section / Proceedings
Keywords: Acrylamide, Robusta Coffee, Urine Production, Blood Pressure, Renal Histopathology
Subjects: R Medicine > RB Pathology
Divisions: Faculty of Medicine > Department of Medicine (11201)
Depositing User: dr Dian Yuliartha Lestari
Date Deposited: 01 Sep 2018 05:23
Last Modified: 04 Dec 2018 01:39
URI : http://eprints.umm.ac.id/id/eprint/37363

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