Exploring Public Health Benefits of Dolichos Lablab as A Dietary Supplement During The COVID-19 Outbreak: A Computational Study

Purwanti, Elly and Eko Hermanto, Feri and Wiliem Souhaly, Jantje and Prihanta, Prihanta and Indria Permana, Tutut (2021) Exploring Public Health Benefits of Dolichos Lablab as A Dietary Supplement During The COVID-19 Outbreak: A Computational Study. Journal of Applied Pharmaceutical Science, 11 (2). pp. 135-140. ISSN 22313354

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Abstract

The emerging case of coronavirus disease-19 (COVID-19) caused by the severe acute respiratory syndromecoronavirus
(SARS-CoV-2)
virus has become a global health issue. Since there is no available developed vaccine,
health-promoting
foods play a vital role in maintaining the immune system against the disease. Dolichos
lablab (DL),

an
unutilized
highly
nutritional
legume,
has
an
excellent
potential
to
cope
with
this
pandemic
with
various
health
benefit

phytochemicals.
This
study appraised the possibility of phytochemical content from DL
to prevent virus infection
and

hyperinflammation in COVID-19 in silico. DL’s phytochemicals from liquid chromatography–high-resolution
mass spectrometry analysis were docked with several SARS-CoV-2 proteins, including main protease and HR. Also,
NF-κB docking was executed to pursue anti-inflammatory properties. The drug-likeness properties of screened
phytochemicals were then evaluated using SwissADME. According to the results, there were 16 phytochemicals with
a high affinity to targeted proteins. Among those, five phytochemicals consistently gave a low binding affinity to all
targeted proteins. Those five phytochemicals’ physicochemical properties, except for rutin and (9cis)-retinal, also
coped with small-molecule bioavailability, permeability, and flexibility according to the SwissADME calculations. In
conclusion, DL has a high probability of complementing the medical effort as dietary supplementation to modulate the
immune system and prevent viral infection.

Item Type: Article
Keywords: COVID-19, Dolichos lablab, heptad repeat, main Protease, NF-κB.
Subjects: L Education > L Education (General)
Q Science > Q Science (General)
Divisions: Faculty of Teacher Training and Education > Department of Biology Education (84205)
Depositing User: wahyuprihanta Wahyu Prihanta, Drs., M.Kes.
Date Deposited: 19 Jan 2024 05:56
Last Modified: 19 Jan 2024 05:56
URI: https://eprints.umm.ac.id/id/eprint/2651

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