“PENGARUH PEMBERIAN BERBAGAI DOSIS JUS JERUK MANIS (Citrus sinensis) TERHADAP KADAR GSH (Glutation sulfhidril) HATI TIKUS PUTIH (Rattus norvegicus) YANG DIPAPAR ASAP ROKOK”

KHAIRA HASNIY, FARIDHA (2009) “PENGARUH PEMBERIAN BERBAGAI DOSIS JUS JERUK MANIS (Citrus sinensis) TERHADAP KADAR GSH (Glutation sulfhidril) HATI TIKUS PUTIH (Rattus norvegicus) YANG DIPAPAR ASAP ROKOK”. Other thesis, University of Muhammadiyah Malang.

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Abstract

Cigarette smoke contains more than 4.000 of toxicant and free radicals or oxidant which can cause the oxidative stress on the lung, liver, and the other organs in our body. The oxidative stress itself has a relationship with the pathogenesis of some chronic diseases such as cancer and chronic obstructive pulmonary disease that may lead to the death. The sweet orange studies was showed that it has flavonoid which has potential antioxidant activity. The aim of this research was to prove that sweet orange juice intake can increase GSH levels Liver of rat which were exposed to cigarette smoke. This research was a true experimental study with post test only control group design. The twenty five (25) white rats are divided into five groups. The first group or A group is the control group (exposed to cigarette smoke), the second group or B group belongs to those exposed to cigarette smoke accompanied with the intake of sweet orange juice in dose 1 ml/200gr body weight, the third group or the C group belongs to those exposed to cigarette smoke accompanied with the intake of sweet orange juice in dose 1,3 ml/200gr body weight, the fourth group or the D group belongs to those exposed to cigarette smoke accompanied with the intake of sweet orange juice in dose 1,7 ml/200gr body weight, the fifth group or the E group belongs to those exposed to cigarette smoke accompanied with the intake of sweet orange juice in dose 2 ml/200gr body weight. Cigarette smoke was given twice in a day: in the morning and in the afternoon along 30 days. All the data were analyzed by using normality assumption, homogeneity, the one way anova and the Duncan’s test. The GSH resulted was A. 0.20, B 0.32, C 0.36, D 0.42, E 0.45. The B, C, D, and E groups are considered to bring significant influence compared to the A group. And the E group has the highest score compared to the others. This show that the sweet orange juice can significantly affect the level of GSH in rat liver which were exposed to cigarettes smoke.

Item Type: Thesis (Other)
Subjects: Q Science > Q Science (General)
Divisions: Faculty of Teacher Training and Education > Department of Biology Education
Depositing User: Anwar Jasin
Date Deposited: 14 Jun 2012 06:26
Last Modified: 14 Jun 2012 06:26
URI: http://eprints.umm.ac.id/id/eprint/7850

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