EFEK ANTI MIKROBA EKSTRAK RIMPANG TEMULAWAK (Curcuma xanthorrhiza) TERHADAP PERTUMBUHAN Staphylococcus aureus

RETNO MASHITA, ARDIANA (2008) EFEK ANTI MIKROBA EKSTRAK RIMPANG TEMULAWAK (Curcuma xanthorrhiza) TERHADAP PERTUMBUHAN Staphylococcus aureus. Other thesis, University of Muhammadiyah Malang.

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Abstract

Staphylococcus aureus is prime pathogen for human that have invasive character. Drugs of choice for Staphylococcus aureus are penicillin, cephalosporin, vancomycin, and erythromycin. Antibiotics have side effects and expensive, so people are interested to use traditional medicines, one of the traditional medicines is curcuma xanthorriza. Curcuma xanthorriza is supposed to have antimicrobial effect because it is contains atsiri oil as active substance, it is work by damage to cytoplasma membrane. This research to proof the antimicrobial effect of curcuma xanthorriza extract to growth of Staphylococcus aureus with using Post Test Only Control Group Design. Method being used is tube dilution test with 8 curcuma xanthorriza concentrations: 100%, 50%, 25%, 12.5%, 6.25%, 3.125%, 1.56%, 0.78% and 2 controls (material control and germ control). Analysis of data using one way ANOVA, correlation, and regression. MIC ( Minimal Inhibitory Concentration) from the experiment can not be certained because extract used higher concentration, the extract colour more turbid, while MBC (Minimal Bactericidal Concentration) is on 6.25% concentration. One way ANOVA test shows significant difference between curcuma xanthorriza extract concentration (p = 0.000). Higher curcuma xanthorrizaextract concentration, higher ability to inhibit and bactericid Staphylococcus aureus (r = ­0.788). Curcuma xanthorriza extract influences reduce large amount of Staphylococcus aureus colony (R2=62,1%). Curcuma xanthorriza extract have antimicrobial effect to growth of Staphylococcus aureus.

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