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PRASWITASARI, RENGGANIS (2008) EFEK DEKOK DAUN PEGAGAN (Centella asiatica) SEBAGAI ANTIMIKROBA TERHADAP Escherichia coli. Other thesis, University of Muhammadiyah Malang.


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Diarrhea is still the major health problem in Indonesia. One of prominent causes of diarrhea in Indonesia is pathogenic Escherichia coli. Many antibacterials, which are commonly used today, scientifically have been proved for their effectiveness in controlling the Escherichia coli infection. However, in their daily uses the resistance problem still appear to be the negative effect. Most recent antibacterial generation that provides more satisfying result is econimically unfforable. Thus, those who cannot afford to buy it tend to use traditional herbs as the best alternative. The usual herb used, which can be easily found in Indonesia, is pegagan (Centella asiatica). Therefore, this research aims at analyzing the effect of pegagan leaves decoction as antibacterial on the multiplication of Escherichia coli using invitro method by which the data of Minimal Inhibitory Concentration (MIC) and Minimal Bactericidal Concentration (MBC) will be taken. This research design is laboratoric experimental using Post test only control with tube dilution test. The bacteria used in this research was taken from faeces speciment of diarrhea patient, whereas, the dose of the pagagan leaves decoction which is used to control themultiplying bacteria were 0%, 3,125%, 6,25%, 12,5%, 25%, 50% which are analized with one way anova, correlation, regression. The result of this research showed that MIC was 25% and MBC was 50%. From the result one way ANOVA test, it was found that (p)=0,000, means that there was a significant difference between the colony number and the groups undertreatment. Another statistical analysis conducted was correlation­regression. The result of the test was p<0,05 and the correlation coefficient (R) was ­0,949. Those two showed us that there was a great relation between the concentration of pegagan leaves decoction with the colony number of E. coli. The higher concentration of the decoction, the more number of the colony was decreasing. From the explanation, it can be concluded that pegegan leaves decoction is affective as antibacterial from E. coli in it Minimal Inhibitory Concentration (MIC) 25% and Minimal Bactericidal Concentration (MBC) 50%.

Item Type: Thesis (Other)
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > Department of Medicine (11201)
Depositing User: Anggit Aldila
Date Deposited: 28 May 2012 03:49
Last Modified: 28 May 2012 03:49

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