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Effect of Extract Black Cumin (Nigela Sativa) on the LDL/HDL Ratio of Ovariectomized White Mouse (Rattus Novergicus Strain Wistas)

Andriana, Kusuma and Nelasari, Halida and Wiyasa, I Wayan Arsana (2015) Effect of Extract Black Cumin (Nigela Sativa) on the LDL/HDL Ratio of Ovariectomized White Mouse (Rattus Novergicus Strain Wistas). Advances in Environmental Biology, 9 (23). pp. 229-232. ISSN 1995-0576

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Abstract

Changes in fat metabolism by estrogen deficiency is one of the factors increasing the risk of CHD in postmenopausal women. Black cumin (Nigella sativa) is a spice that can be used as a medicinal plant. From several studies, Nigella sativa could show the effects of estrogen. Objective: to determine the effect of black cumin (Nigella sativa) against changes on LDL/HDL ratio of the ovariectomized white mouse (Rattus novergicus wistar strain) Method : True Experimental design with the post test only control group design with 25 female mouse divided into five groups : 2 controle group positive and negative, and 3 treatment groups of black cumin extract at a dose of 1.25, 2.5 and 5 mg/kg BW /day. Results : One way ANOVA test showed the non significant value (p > 0.05) of weight changes (p: 0.055), HDL level (p : 0.326) and LDL level ( p: 0.659). At Kruskal-Wallis test showed the non significant value of LDL/HDL ratio (p : 0.152 (p > 0.05)). Conclusion : Extract of black cumin (N. sativa) could not significant affect on LDL/HDL ratio of the ovariectomized white mouse (Rattus novergicus wistar strain)

Item Type: Article
Keywords: black cumin extract, menopause, LDL, HDL, LDL/HDL ratio
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > Department of Medicine (11201)
Depositing User: Bakhtiar Effendi
Date Deposited: 06 Jan 2020 04:05
Last Modified: 06 Jan 2020 04:05
URI : http://eprints.umm.ac.id/id/eprint/57894

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