PENGARUH FORMALIN TERHADAP MUKOSA YEYUNUM TIKUS PUTIH (Rattus norvegicus strain wistar)

NURMASARI, NURMASARI (2008) PENGARUH FORMALIN TERHADAP MUKOSA YEYUNUM TIKUS PUTIH (Rattus norvegicus strain wistar). Other thesis, University of Muhammadiyah Malang.

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Abstract

Background : Cancer of intestinum tenue are frequently present comparatively late in their natural history as it has less symptoms and diagnostic difficulty. Most of these tumors are found at surgery indicated for other diagnosis or intestinal obstruction with widespread metastatic. Formalin usually misused especially in food industry and if it’s consumed could cause the deviation of the body . Purpose : Prove the effect of formalin on Wistar rat’s jejunal mucous (Rattus norvegicus strain wistar). Research Methode : The design of the study was pure experimental using The Posttest Control Group Design. Samples were Wistar Rats divided into 4 groups. Group I as a control which is not given formalin, and the other groups were given formalin dosed 20 ppm, 40 ppm, and 80 ppm. Result and discussion : The results shown that formalin caused hyperplasia, hypertrophy, atrophy and inflammation (ANOVA p = 0.000). The changes of rat’s jejunal mucous were probably caused by the binded DNA by the protein that affect the normal genetic expression. Conclusions : The study proved that formalin caused the changes of Wistar rat’s jejunal mucous, and further study was needed to support clinical application.

Item Type: Thesis (Other)
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > Department of Medical Education
Depositing User: Anggit Aldila
Date Deposited: 22 May 2012 03:53
Last Modified: 22 May 2012 03:53
URI: http://eprints.umm.ac.id/id/eprint/5685

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