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STUDI PENGGUNAAN CEFTRIAXONE PADA PASIEN SIROSIS HATI DENGAN SPONTANEOUS BACTERIAL PERITONITIS (SBP)

Ni'mah, Khairun (2019) STUDI PENGGUNAAN CEFTRIAXONE PADA PASIEN SIROSIS HATI DENGAN SPONTANEOUS BACTERIAL PERITONITIS (SBP). Undergraduate (S1) thesis, University of Muhammadiyah Malang.

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Abstract

Background: Cirrhosis is an end-stage of chronic liver disease characterized by fibrosis and nodule formation which leads to significant obstructions and circulations of the liver. Patients with cirrhosis are at high risk of developing complications such as ascites. Ascites resulting bacteremia and subsequent colonization of susceptible ascitic fluid, developing to spontaneous bacterial peritonitis (SBP). SBP is the most prevalent infection in patients with cirrhosis and is diagnosed in one-quarter of cirrhosis patients hospitalized with bacterial infections. The first line therapy for SBP consists of third-generation cephalosporins as empiric antibiotic, such as ceftriaxone. This antibiotic effective in 95% of the flora including Escherichia coli, Klebsiella pneumoniae, and Streptococcal pneumoniae. Objective: Aimed to know the pattern of use of ceftriaxone in cirrhosis patients with SBP in RSUD Sidoarjo from January 2018 – May 2019. Method: Observational study by intake data retrospectively and consecutive sampling method in cirrhosis patients with SBP in RSUD Sidoarjo from January 2018 – May 2019. Results and Conclusions: The pattern of single use of ceftriaxone used in 12 patients (92%), and combination two used in 1 patient (8%). The single use of ceftriaxone only used with regimentation (2x1 g) IV in 12 patients (92%). The use of combination two ceftriaxone (2x1 g) IV + metronidazole (3x500 mg) IV used in 1 patient (8%). The pattern of switch use of antibiotics used in 3 patients, consist of ceftriaxone (2x1 g) IV  cefotaxime (3x2 g) IV used in 2 patients (67%), and cefoperazone (3x1 g) IV  ceftriaxone (2x1 g) IV used in 1 patient (33%).

Item Type: Thesis (Undergraduate (S1))
Student ID: 201510410311128
Thesis Advisors: Didik Hasmono, Lilik Yusetyani (0714095802)
Keywords: Ceftriaxone, SBP, Cirrhosis
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Health Science > Department of Pharmacy (48201)
Depositing User: 201510410311128
Date Deposited: 16 Oct 2019 09:18
Last Modified: 16 Oct 2019 09:18
URI : http://eprints.umm.ac.id/id/eprint/53888

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