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PENGARUH EKSTRAK MENIRAN (Phyllanthus niruri L.) TERHADAP KADAR MALONDIALDEHID (MDA) PLASMA DARAH TIKUS PUTIH (Rattus norvegicus strain wistar) YANG DIPAPAR TIMBAL ASETAT

Ma'rufah, Annisa' (2019) PENGARUH EKSTRAK MENIRAN (Phyllanthus niruri L.) TERHADAP KADAR MALONDIALDEHID (MDA) PLASMA DARAH TIKUS PUTIH (Rattus norvegicus strain wistar) YANG DIPAPAR TIMBAL ASETAT. Bachelors Degree (S1) thesis, University of Muhammadiyah Malang.

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Abstract

Background: Oxidative stress can trigger lipid peroxidation that produces malondialdehyde (MDA) as an indicator. Meniran extract as an antioxidant can reduce free radicals from lead acetate exposure. Objective: To determine the effect of meniran extract on white rats MDA blood plasma levels exposed by lead acetate. Method: True experiment with post-test only control group design. 20 rats were divided into five groups; negative control group, positive control group, and 3 treatment groups (exposed by lead acetate and extract 20, 40, and 80 [mg/200grams weight/day]). Data were analysed by One Way Anova, Post Hoc Bonferroni, and linear regression test. Result & Discussion: The One Way Anova test results showed a significant difference in MDA levels (p = 0,000). Post Hoc test results obtained a dose of 80 mg / 200gram weight / day had a significant reduction in MDA levels (p=0,001). The results of the regression test were significant (p = 0,000) indicated there was a relationship between the dose of meniran extract and white rats MDA blood plasma levels. This is due to tannin and vitamin C in meniran increase endogenous antioxidant in rats with oxidative stress. Conclusion: Meniran extract (Phyllanthus niruri L.) has an effect on decreasing white rats MDA blood plasma level which exposed by lead acetate.

Item Type: Thesis (Bachelors Degree (S1))
Student ID: 201510330311093
Corporate Creators: Sulistyo M. Agustini (0711086202), Rahayu (0728026601)
Keywords: Lead Acetate, Meniran Extract (Phyllanthus niruri L.), Antioxidant, MDA
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Medicine > Department of Medicine (11201)
Depositing User: 201510330311093
Date Deposited: 15 Aug 2019 08:30
Last Modified: 15 Aug 2019 08:30
URI : http://eprints.umm.ac.id/id/eprint/49096

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