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STUDI VIABILITAS BAKTERI DI USUS BESAR MENCIT (Mus musculus) PADA PEMBERIAN EKSTRAK ETANOL Myrmecodia sp. YANG DIINFEKSI Shigella dysenteriae

Ramadhani, Khairil (2019) STUDI VIABILITAS BAKTERI DI USUS BESAR MENCIT (Mus musculus) PADA PEMBERIAN EKSTRAK ETANOL Myrmecodia sp. YANG DIINFEKSI Shigella dysenteriae. Bachelors Degree (S1) thesis, University of Muhammadiyah Malang.

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Abstract

Background: Shigella bacteria are Gram-negative, non-motile bacilli belonging to the Enterobacteriacae family. Shigella dysenteriae cause acute bloody diarrhea by invading and causing evenly distributed colon epithelial damage. This results in the formation of micro ulcers and inflammatory exudates, causing inflammatory cells (polymorphonuclear leukocytes, PMN) and blood to appear in the stool. Plants identified as having an antibacterial effect are ant nest plants (Myrmecodia sp.). Objective: This study aimed to obtain the optimum data and dosage of ethanol extract of ant nest tubers (Myrmecodia sp.) On the viability profile of Shigella dysentriae bacteria in the large intestine of mice carried out in vivo. Method: This study used post test only control group design, 24 male Mus musculus were divided into 6 groups, namely healthy control group, positive control group, negative control group and 3 treatment groups (P1, P2, and P3). This research was conducted for 14 days. The amount of viability is measured based on the total plate count using a colony counter. The data obtained were analyzed using the One Way ANOVA method. Results and Conclusions: The results showed that the ethanol extract of ant nest tubers at a dose of 0.025 g / kgBB, 0.050 g / kgBB, and 0.100 g / kgBB could provide antibacterial effects. Effective dose to inhibit bacterial growth is the administration of ethanol extract of ant nest tubers at a dose of 0.100 g / kgBB.

Item Type: Thesis (Bachelors Degree (S1))
Student ID: 201510410311123
Thesis Advisors: Siti Rofida (0728087904), Ahmad Shobrun Jamil (0721018502)
Keywords: Myrmecodia, Shigella dysenteriae, dysentery, bacteria, viability.
Subjects: Q Science > QK Botany
Q Science > QR Microbiology
R Medicine > RS Pharmacy and materia medica
R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions: Faculty of Health Science > Department of Pharmacy (48201)
Depositing User: 201510410311123
Date Deposited: 15 Aug 2019 01:58
Last Modified: 15 Aug 2019 01:58
URI : http://eprints.umm.ac.id/id/eprint/48887

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