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STUDI PENGGUNAAN KOMBINASI ANTIBIOTIK SEFAZOLIN DENGAN GENTAMISIN PADA PASIEN OPEN FRACTURE GRADE III (Penelitian Dilakukan Di Rumah Sakit Umum Dr. Saiful Anwar Malang)

Ayuningsih, Septiani Tri (2019) STUDI PENGGUNAAN KOMBINASI ANTIBIOTIK SEFAZOLIN DENGAN GENTAMISIN PADA PASIEN OPEN FRACTURE GRADE III (Penelitian Dilakukan Di Rumah Sakit Umum Dr. Saiful Anwar Malang). Bachelors Degree (S1) thesis, University of Muhammadiyah Malang.

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Abstract

Background : Fractures are partial or complete damage to bone structural continuity and are divided according to type and area. Open fracture is classified to be grade III if the wound is open >10cm with extensive soft tissue damage, and a higher risk of infection. Pathogens in orthopedic surgery are Staphylococcus aureus, gram-negative bacilli, Staphylococcus epidermidis, b-hemolytic Streptococcus, Aerobic and Anaerobic cocci. For this reason, a combination of Cefazolin and Gentamicin is required in grade III open fracture, where Gentamicin which is active in gram-negative germs if given along with antibiotics that are active against cell walls and gram-positive germs such as Cefazolin, will provide a synergistic annihilation (bactericidal) effect. Objectives : A study to knowing the pattern of using antibiotic Cefazoline with Gentamicin in open fracture grade III patients at RSSA Malang for the period of 1 January 2016 - 31 December 2018. Method : Observational by descriptive research design and retrospective data at patients with Open fracture at Regional Public Hospital of Dr. Saiful Anwar Malang in 1 January 2016 - 31 Desember 2018. Result and Conclusion : The result of 16 samples show that the pattern of using antibiotic Cefazolin with Gentamicin combination in open fracture grade III patients, most of them received a Cefazolin (3x1g) iv with Gentamicin (2x80mg) iv in 13 patients (82%), and most antibiotic switching is Cefazolin (1x2g) iv switched Cefazolin (3x1g) iv with Gentamicin (2x80mg) iv, and then switched to Cefadroxil (2x500mg) po, in 5 patients (24%). Keywords : Cefazolin, Gentamicin, Open Fracture, Grade III

Item Type: Thesis (Bachelors Degree (S1))
Student ID: 201510410311047
Thesis Advisors: Hidajah Rachmawati, Didik Hasmono
Keywords: Cefazolin, Gentamicin, Open Fracture, Grade III
Subjects: L Education > L Education (General)
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Health Science > Department of Pharmacy (48201)
Depositing User: 201510410311047
Date Deposited: 10 Aug 2019 01:52
Last Modified: 10 Aug 2019 01:52
URI : http://eprints.umm.ac.id/id/eprint/48441

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