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Uji Efektivitas Ekstrak Daun Bidara (Ziziphus Mauritiana Lam) Terhadap Ketebalan Ventrikel Kiri Jantung Tikus Putih (Rattus Norvegicus Strain Wistar) Model Hipertensi

Zukruf, Fiirhan Ikhyana (2019) Uji Efektivitas Ekstrak Daun Bidara (Ziziphus Mauritiana Lam) Terhadap Ketebalan Ventrikel Kiri Jantung Tikus Putih (Rattus Norvegicus Strain Wistar) Model Hipertensi. Bachelors Degree (S1) thesis, University of Muhammadiyah Malang.

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Abstract

Zukruf, Firhan Ikhyana. 2019, “Effectivity Test of Jujube Leaves Extract (Ziziphus mauritiana Lam) On Left Ventricular Thickness in Hypertensive Rats (Rattus norvegicus strain wistar).” Final Assignment of Medical Faculty of Muhammadiyah Malang University. Advisors : (I) Dian Yuliarta Lestari, (II) Rahayu. Background: Left ventricular hyperthropy is one of complications from hypertension. it caused by long term exposure of high blood pressure. Jujube leaves has lowering blood pressure because of its ACE inhibitors content and antioxidant activity. Objective: To test the effectivity of jujube leaves extract (Ziziphus mauritiana Lam) on left ventricular thickness in hypertensive rats (Rattus norvegicus strain wistar). Method: Method used is true experimental with Post test-only control group design. Rats were divided into 5 groups : captopril group (0,225mg/200mgBW) , positive group, P1 (200mg/kgBW jujube leaves extract), P2 (400mg/kgBW jujube leaves extract), dan P3 (800mg/kgBW jujube leaves extract). One group consist of 5 rats and experiment was carried for 28 days. Rats heart was taken and stained with hematoxylin eosin. Rats heart was observed in 400x magnification and measured with optilab. The result measured with One-Way ANOVA, Post Hoc Bonferroni dan Linear Regression Result: All groups were found to be not significant in One-Way ANOVA test (P>0,05). Factors that can affect this result including fibrotic remodeling, short treatment time, and the presence of intracellular angiotensin II mechanism. Conclusion: Jujube leaves extract has no significant effect on left ventricular thickness in hypertensive rats. Keyword: Hypertension, Left Ventricular Thickness, jujube leaves

Item Type: Thesis (Bachelors Degree (S1))
Student ID: 201510330311137
Corporate Creators: Dian Yuliarta Lestari, Rahayu
Keywords: Hypertension, Left Ventricular Thickness, jujube leaves
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > Department of Medicine (11201)
Depositing User: 201510330311137
Date Deposited: 16 Jul 2019 01:43
Last Modified: 16 Jul 2019 01:43
URI : http://eprints.umm.ac.id/id/eprint/47027

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