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PENGARUH MINYAK ATSIRI BIJI PALA (Myristica fragrans Houtt) MENGGUNAKAN METODE DESTILASI AIR TERHADAP PERTUMBUHAN Candida albicans SECARA IN VITRO

Aini, Siti Sofiatul (2019) PENGARUH MINYAK ATSIRI BIJI PALA (Myristica fragrans Houtt) MENGGUNAKAN METODE DESTILASI AIR TERHADAP PERTUMBUHAN Candida albicans SECARA IN VITRO. Undergraduate (S1) thesis, University of Muhammadiyah Malang.

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Abstract

Background: Fungi has been identified as the cause of various infections diseases, one of the pathogenic species causes invasive candidasis which is commonly found is Candida albicans, it can cause high mortality 64,8% in RSCM Jakarta. Nutmeg essential oil indicited to contain that can obstruct and destroy of Candida albicans, such hydrocarbon monoterpenes consisting of sabinen, α pinen, β pinen, which could damage cell membranes, cell walls, mitochondria, disrupting fungal sporulation and germination. Purpose: To understand the effect of Nutmeg essential oil (Myristica fragrans Houtt) using a water distillation method for growth Candida albicans in vitro. Research Methods: Experimental post test only control group design, using dilution tubes with Essential oil of Nutmeg (Myrisica fragrans Houtt) concentration 100%, 1.56%, 0.78%, 0.39%, 0.195%, 0.0975%, 0, 04875%, 0%. Data were analyzed by using One Way ANOVA test, Post Hoc Tamhane, Pearson Correlation, and linear regression. Discuss and Results: The MIC 0,0975% and MLC 0.195%. One Way ANOVA test (p = 0,000) showed a significant difference between treatments. Tamhane Post Hoc Test found different notations between treatments. Pearson Correlation Test -0,961 (p = 0,000) it means has a very strong relation. Linear regression test, showed adjusted R square 92.4%, it means by giving of nutmeg essential oils had affected to decrease number of Candida albicans colonies. It cause by functioning active ingredients of nutmeg are sabinen, α pinen, β pinen as antifungal. Conclusion: The Essential Oil of Nutmeg (Myristica fragrans Houtt) had effect obstructing and destroying the growth of Candida albicans in vitro. Keyword: Essential Oil of Nutmeg, Candida albicans, MIC, MLC.

Item Type: Thesis (Undergraduate (S1))
Student ID: 201510330311084
Thesis Advisors: Irma Suswati, Pertiwi Febriana Chandrawati
Keywords: Essential Oil of Nutmeg, Candida albicans, MIC, MLC.
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > Department of Medicine (11201)
Depositing User: 201510330311084
Date Deposited: 15 Jul 2019 09:24
Last Modified: 15 Jul 2019 09:24
URI : http://eprints.umm.ac.id/id/eprint/47025

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