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PENGARUH KADAR BAHAN PENGIKAT HPMC 2910 5 cps TERHADAP MUTU FISIK TABLET EKSTRAK DAUN TEMPUYUNG (Sonchus arvensis L.)

Hapysari, Yulinda Pristi Dwi (2019) PENGARUH KADAR BAHAN PENGIKAT HPMC 2910 5 cps TERHADAP MUTU FISIK TABLET EKSTRAK DAUN TEMPUYUNG (Sonchus arvensis L.). Undergraduate (S1) thesis, University of Muhammadiyah Malang.

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Abstract

Background: Tempuyung (Sonchus arvensis L.) are one of the medicinal plants that are efficacious as a destroyer of kidney stone. In this study a tempuyung leaf extract tablet formula was developed that met the requirements. Objective: The purpose of this study is to determine the effect of HMPC 2910 5 cps concentration 1%, 2%, and 3% as a binder on the physical quality of tempuyung leaf extract tablets and to determine the optimum concentration of HPMC 2910 5 cps that can meet the required physical quality, Metode: The extract of tempuyung leaf by utilizing kinetic maceration method using 96% ethanol as the solvent. The tablets was made by using wet granulation method utilizing HPMC 2910 5cps as the binding agent. The examination of physical quality of the tablets includes the hardness, friability, and the tablets disintegration time, then analyzed statistically. Result and Conclusions: The result of the study indicated that the increase of HPMC 2910 5 cps concentration was able to increase the hardness and disintegration time, and decrease the friability of the tablets. The result of the statistical analysis showed a significant difference between the formula for tablet hardness and the disintegration time. While, it was significantly differencein terms of friability in the formula with the concentration of 2% and 3%. The tempuyung extract tablet with levels of HMPC 2910 5cps 1% (F2) is the selected of formula that meet the requirements.

Item Type: Thesis (Undergraduate (S1))
Student ID: 201410410311086
Thesis Advisors: University of Muhammadiyah Malang
Keywords: Tempuyung Leaf Extract, HPMC 2910 5 cps, Wet Granulation, Tablets
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Health Science > Department of Pharmacy (48201)
Depositing User: Nurhadin Nurhadin
Date Deposited: 09 Jul 2019 03:53
Last Modified: 09 Jul 2019 03:53
URI : http://eprints.umm.ac.id/id/eprint/46850

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