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PENGARUH PEMBERIAN KOMBINASI EKSTRAK JAHE, KAYU MANIS, DAN CENGKIH TERHADAP KADAR SGOT DAN SGPT PADA TIKUS YANG DIINDUKSI STREPTOZOTOCIN

Harianto, Fadhillah Ainurrohmah (2019) PENGARUH PEMBERIAN KOMBINASI EKSTRAK JAHE, KAYU MANIS, DAN CENGKIH TERHADAP KADAR SGOT DAN SGPT PADA TIKUS YANG DIINDUKSI STREPTOZOTOCIN. Bachelors Degree (S1) thesis, University of Muhammadiyah Malang.

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Abstract

Background: Ginger, cinnamon and clove extract with polyphenol, flavonoids, saponins, tannins as antioxidants is considered has function as a hepatoprotector. Eugenol is a dominant compound from the identification of these extract that prevented increases in AST and ALT serum level through oxidative stress pathway. Objective: To know the effect of Ginger, cinnamon and clove extract on the changing of the AST and ALT serum level on Streptozotocin Induced Rats. Method: True experimental with post test only control group design. The sample of rats were divided into 8 groups: 1 control group and 8 treatment groups were given STZ dose 60 mg/gramBW, ginger extract 100 mg/gramBW/day, cinnamon extract 100 mg/gramBW/day, clove extract 100 mg/gramBW/day, combination of ginger, cinnamon and clove extract 25 mg/gramBW/day, combination of ginger, cinnamon and clove extract 50 mg/gramBW/day and combination of ginger, cinnamon and clove extract 100 mg/gramBW for 14 days. Data were analyzed using normality test, homogeinity test, kruskal-wallis, one way annova, post hoc bonferoni, pearson and linier regression. Result and Discussion: The extract of ginger, cinnamon, clove and its combination did not showed significant difference between groups with p=0,092. The result of post hoc bonferoni, Pearson and linier regression could not be tested because not quilfy in normality and homogeinity test between control group and each treatment groups. Non-parametric test showed no significant result. In the descriptive results, it has been concluded that most of group except cinnamon extract dose 100 mg/gramBW/day has an increased serum level of AST and ALT. Conclusion: There is no significant effect of ginger, cinnamon, clove and its combination extract

Item Type: Thesis (Bachelors Degree (S1))
Student ID: 201510330311110
Keywords: AST, ALT, Ginger, Cinnamon, Clove, Combination, Streptozotocin
Subjects: R Medicine > RA Public aspects of medicine > RA1001 Forensic Medicine. Medical jurisprudence. Legal medicine
Divisions: Faculty of Medicine > Department of Medicine (11201)
Depositing User: Retno Widiyastuti Ika Wijaya
Date Deposited: 08 Jul 2019 02:49
Last Modified: 08 Jul 2019 02:49
URI : http://eprints.umm.ac.id/id/eprint/46804

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