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PENGARUH PEMBERIAN ETAMBUTOL, PIRAZINAMID DAN LEVOFLOKSASIN TERHADAP KADAR SITOKIN INTERLEUKIN-6 PADA TIKUS PUTIH (Rattus norvegicus strain wistar)

Muhaimin, Alim (2019) PENGARUH PEMBERIAN ETAMBUTOL, PIRAZINAMID DAN LEVOFLOKSASIN TERHADAP KADAR SITOKIN INTERLEUKIN-6 PADA TIKUS PUTIH (Rattus norvegicus strain wistar). Bachelors Degree (S1) thesis, University of Muhammadiyah Malang.

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Abstract

Background: Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. TB patients themselves can become multidrug-resistant TB because of disobedience to take medication. The treatment for tuberculosis uses some kinds of drugs, some of those are ethambutol, pyrazinamide, and levofloxacin. When human's body takes tuberculosis drugs that act as antibiotics, it will cause the reaction hypersensitivity, which also can increase the amount of cytokine IL-6. IL-6 can be used as an indicator of inflammation to monitor the side effects of drugs such as hepatotoxic. Objective: To identify the effect of giving Ethambutol, Pyrazinamide, and Levofloxacin towards the amount of Cytokine Interleukin-6 in male White Rats (Rattus norvegicus strain wistar). Methods: True experimental research, post test control group design. Rats divided into 2 groups (negative and positive control). Positive control group was given tuberculosis drugs through sonde, while the negative control group was only given BR-1 and water. Results: From the research, there was found the increasing of the amount of cytokine IL-6 in the positive control group. The amount of cytokine IL-6 in the negative control group was 6.5ng/ml while in the positive control group increased to 7.9ng/ml. Antibiotics in tuberculosis drugs will cause the response of hypersensitivity and inflammation inside human's body. Hypersensitivity response and inflammation cause the increase of cytokine IL-6 which is a cytokine pro-inflammatory. Conclusion: Presenting that was increasing in the amount of cytokine IL-6 in positive control grup, but statistically the results were not significant.

Item Type: Thesis (Bachelors Degree (S1))
Student ID: 201510330311037
Keywords: Tuberculosis drugs, Inflammation, Interleukin-6.
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > Department of Medicine (11201)
Depositing User: Nurhadin Nurhadin
Date Deposited: 25 Apr 2019 01:43
Last Modified: 25 Apr 2019 01:43
URI : http://eprints.umm.ac.id/id/eprint/45992

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