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PENGARUH EKSTRAK DAUN PEPAYA (Carica papaya L.) TERHADAP PERSENTASE DEGENERASI LUMEN TUBULUS KONTORTUS PROKSIMAL GINJAL TIKUS PUTIH JANTAN (Rattus norvegicus strain wistar) YANG DIINDUKSI MSG

Kurniawati, Adiningtyas (2019) PENGARUH EKSTRAK DAUN PEPAYA (Carica papaya L.) TERHADAP PERSENTASE DEGENERASI LUMEN TUBULUS KONTORTUS PROKSIMAL GINJAL TIKUS PUTIH JANTAN (Rattus norvegicus strain wistar) YANG DIINDUKSI MSG. Bachelors Degree (S1) thesis, University of Muhammadiyah Malang.

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Abstract

Background: Monosodium glutamate (MSG) is one of free radical and excreted through the kidney which can damage lumen epithelial cells of proximal tubular. Carica papaya leaf contains flavonoid, phenolic & alkaloid, saponin, and vitamin C that can inhibit free radicals activity on lumen epithelial cells of proximal tubular. Objective: To determine the effect of Carica papaya leaf extract on number of proximal tubular lumen degeneration in white rat kidney orally induced by MSG. Methods: True experimental with post-test only control group design. 12 mice were divided into four groups, a group was given MSG 5mg/grbw/day and aquadest, and three others were given MSG and Carica Papaya Leaf extract 30; 60; 120 (mg/200grbw/day). Data were analyzed using SPSS 24 software. Result and Discussion: One way ANOVA test resulted in significant influence (p:0,000). Post hoc test resulted significant difference (p: <0,05) in 60mg/200grbw/day. Linear regression resulted in AR Square: 0,886 (Carica Papaya L. extract had 88,6% of influence). The number of proximal tubular lumen degeneration decreased because flavonoid, phenolic & alkaloid, saponin, and vitamin C in Carica Papaya L. extract could inhibit free radical activity. Conclusion: Carica papaya Leaf extract could decrease number of proximal tubular lumen degeneration in white rat (Rattus norvegicus strain wistar) kidney induced by MSG.

Item Type: Thesis (Bachelors Degree (S1))
Student ID: 201510330311087
Keywords: Monosodium glutamate (MSG), lumen of proximal tubular, Carica Papaya Leaf, flavonoid, phenolic & alkaloid, saponin, and vitamin C
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > Department of Medicine (11201)
Depositing User: Nurhadin Nurhadin
Date Deposited: 24 Apr 2019 01:43
Last Modified: 24 Apr 2019 01:43
URI : http://eprints.umm.ac.id/id/eprint/45962

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