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PENGARUH PEMBERIAN ETAMBUTOL, PIRAZINAMID DAN LEVOFLOKSASIN TERHADAP KADAR MALONDIALDEHYDE PADA TIKUS PUTIH (Rattus norvegicus) JANTAN STRAIN WISTAR

Ksatria, Abdillah Budi (2019) PENGARUH PEMBERIAN ETAMBUTOL, PIRAZINAMID DAN LEVOFLOKSASIN TERHADAP KADAR MALONDIALDEHYDE PADA TIKUS PUTIH (Rattus norvegicus) JANTAN STRAIN WISTAR. Bachelors Degree (S1) thesis, University of Muhammadiyah Malang.

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Abstract

Background: Multiple Drug Resistance Tuberculosis (MDR-TB) is one type of TB which is resistant to rifampicin and isoniazid simultaneously. Treatments for MDR-TB patients were using first-line and second-line anti-tuberculosis drugs. The use of ethambutol, pyrazinamide, and levofloxacin caused several side effects in the body. Malondialdehyde is one of the final product from the peroxidation of lipids and uses as inflammatory marker. Purpose: The purpose of this research was to find out the effect of giving anti-tuberculosis drugs (ethambutol, pyrazinamide, and levofloxacin) to the levels of malondialdehyde in white male mice (Rattus norvegicus) strain wistar. Methods: True experimental with post-test only control group design. The sample was divided into 2 groups. The numbers of samples in each group were 6 mice. Positive control group was given ethambutol 9 mg/day, pyrazinamide 9 mg/day, and levofloxacin 4.5 mg/day. Negative Control Group was given standard food and drink. Data were analyzed using normality test and unpaired t-test. Results and Discussion: The results of the normality test obtained normal distributed data (p> 0.05). The results of the unpaired t test were obtained p= 0.000, so that there were significant differences between the treatment group or positive control and the negative control group. Ethambutol, pyrazinamide, and levofloxacin will react with the excess oxide and will cause an imbalance between free radicals and antioxidants, resulting in a condition called oxidative stress. Free radicals will bind with Polyunsaturated Fatty acids (PUFA) and will cause damage to the mechanism of lipid concentration. Conclusion: There was a significant effect of anti tuberculosis drugs (Ethambutol, Pirazinamide, and Levofloxacin) on increasing levels of Malondialdehyde in white male mice (Rattus norvegicus) Strain Wistar.

Item Type: Thesis (Bachelors Degree (S1))
Student ID: 201510330311145
Keywords: tuberculosis, ethambutol, pyrazinamide, levofloxacin, Malondialdehyde
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > Department of Medicine (11201)
Depositing User: Nurhadin Nurhadin
Date Deposited: 24 Apr 2019 01:34
Last Modified: 24 Apr 2019 01:34
URI : http://eprints.umm.ac.id/id/eprint/45961

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