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SINTESIS SENYAWA ASAM O-(4-NITROBENZOIL)-5-METILSALISILAT DAN UJI AKTIVITAS ANALGESIK PADA MENCIT (Mus musculus)

Setyaningsih, Yulinda (2018) SINTESIS SENYAWA ASAM O-(4-NITROBENZOIL)-5-METILSALISILAT DAN UJI AKTIVITAS ANALGESIK PADA MENCIT (Mus musculus). Bachelors Degree (S1) thesis, University of Muhammadiyah Malang.

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Abstract

Background: O-(4-nitrobenzoyl)-5-methylsalicylic acid is a derivative of salicylic acid resulting from the synthesis of 5-methylsalicylic acid and 4-nitrobenzoyl chloride with esterification of acyl halide method. Objective: Produce O-(4-nitrobenzoyl)-5-methylsalicylic acid of the reaction process between 5-methylsalicylic acid and 4-nitrobenzoyl chloride and to determine analgesics activity in mice. Method: The synthesis is using esterification method of acyl halide, while the analgesic activity test using stretching method (Writhing test). Result: The result obtained from synthesis is crystalline, yellowish, odorless with a yield percentage of 11,62% with a melting point of 198-200°C. TLC test results obtained 1 stain using 3 eluents: chloroform : methanol (7:3), ethyl acetate : methanol (7:3), ethyl acetate : ethanol (7:3). Identification of structures with the UV spectrophotometer showed the wavelengths 204 nm dan 260 nm. IR spectrophotometer showed the wave number 3420,75 cm-1 (-OH); 2926,61 cm-1 (CH3); 1693,29 cm-1 and 1607,49 cm-1 (C=O); 1541,41 cm-1 (C=C); 1280,38 cm-1 (COOC). The 1H-NMR spectrometer showed 11 H atoms. The percentages of pain inhibition for dose 25 mg/kgBW = 37,05%, 50 mg/kgBW = 55,46%, 100 mg/kgBW = 65,18%. The O-(4-nitrobenzoyl)-5-methylsalicylic acid had ED50 of 44,07 mg/kgBW while the aspirin which is the salicylic acid derivative had ED50 of 135,68 mg/kgBW. Conclusions: O-(4-nitrobenzoyl)-5-methylsalicylic acid was synthesized and had higher activity than aspirin.

Item Type: Thesis (Bachelors Degree (S1))
Student ID: 201410410311243
Keywords: O-(4-nitrobenzoyl)-5-methylsalicylic acid, Esterification of acyl halide, Writhing test
Subjects: R Medicine > RZ Other systems of medicine
Divisions: Faculty of Health Science > Department of Pharmacy (48201)
Depositing User: Nurhadin Nurhadin
Date Deposited: 27 Dec 2018 02:09
Last Modified: 27 Dec 2018 02:09
URI : http://eprints.umm.ac.id/id/eprint/42612

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