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Pengaruh Pemberian Gel Ekstrak Daun Kenikir (Cosmos caudatus) terhadap Sel Fibroblas dan Mononuklear pada Luka Eksisi Tikus Putih Jantan (Rattusnovergicus strain wistar)

Mar’ah, Emeralda Cintya Fikrotul (2018) Pengaruh Pemberian Gel Ekstrak Daun Kenikir (Cosmos caudatus) terhadap Sel Fibroblas dan Mononuklear pada Luka Eksisi Tikus Putih Jantan (Rattusnovergicus strain wistar). Bachelors Degree (S1) thesis, University of Muhammadiyah Malang.

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Abstract

Background: Excision is an open wounds which one of three most common injury in Indonesia with 23,2%. The inappropriate wound healing can lead to chronic wound and increase the infection risk. Kenikir (Cosmos caudatus) can use as anti-inflamation and anti-bacterial that help wound healing. Objective: To determine the effect of kenikir leaves gel extract on fibroblast and mononuclear cell of excision wound healing in white rat Methods: True experimental with post test only control group design. Experimentally-wounded rat were devided into 4 groups, control (treated with basic gel) and kenikir gel-treated (in 50%, 67%, & 80% doses). Each groups consisted of 6 rats and treated for 2 weeks. Healing tissue was collected on day 7 post-wounding for histology studies with HE staining and was observed under a microscope (400x) with pathology anatomy supervisor guidance. Datas were analysed using MANOVA, post hoc Bonferroni and pearson correlation. Results and discussion: The result of analysis test indicated that kenikir (cosmos caudatus) leaves gel extract have significant effect on fibroblast and mononuclear cell in general and each variabel (p<0.05). Conclusion: Kenikir leaves gel extract could increasing fibroblast cell and decreasing mononuclear cell in excision wound healing

Item Type: Thesis (Bachelors Degree (S1))
Student ID: 201310330311021
Thesis Advisors: University of Muhammadiyah Malang
Keywords: Kenikir (cosmos caudatus) leaves gel extract, Fibroblast cell, Mononuklear cell, Excision wound.
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > Department of Medicine (11201)
Depositing User: Nurhadin Nurhadin
Date Deposited: 06 Dec 2018 04:09
Last Modified: 06 Dec 2018 04:09
URI : http://eprints.umm.ac.id/id/eprint/41550

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