Yurista, Salva reverentia and Safithri, Fathiyah and Djunaedi, Djoni and Sargowo, Djanggan (2012) Effect of Extract from Pericarp of Mangosteen (Garcinia Mangostana Linn) as Anti-Inflammatory Agent in Rat Models with Atherosclerosis. Jurnal Kardiologi Indonesia, 33 (1). pp. 4-9. ISSN 0126/3773
|
Text (Peer Review Penulis Kedua)
Peer Review - Safithri - Atherosclerosis Garcinia mangostana Linn anti-inflammatory TNF-a IL-1 IL-6 NF-kB ICAM-1.pdf Download (1MB) | Preview |
|
|
Text
Similarity - Yurista Safithri Djunaedi Sargowo - Atherosclerosis Garcinia mangostana Linn anti-inflammatory TNF-a IL-1 IL-6 NF-kB ICAM-1.pdf Download (3MB) | Preview |
|
|
Text
Yurista Safithri Djunaedi Sargowo - Atherosclerosis Garcinia mangostana Linn anti-inflammatory TNF-a IL-1 IL-6 NF-kB ICAM-1.pdf Download (229kB) | Preview |
Abstract
Background. Atherosclerosis is an inflammatory disease characterized by intense immunological activity, which immune responses participate in every phase of atherosclerosis. On fundamental importance in atherogenesis is nuclear factor-κB (NF- κB) that regulates activation of adhesion molecules (ICAM-1) and secretion of pro-inflammatory cytokines such as tumor necrosis factor (TNF-α) interleukin-1 (IL-1), and interleukin-6 (IL-6). Aims. The extract from pericarp of mangosteen (Garcinia mangostana Linn ) were carried out to investigate for anti-inflammatory activity in rat models with atherosclerosis. Methods. The subjects of the study were 30 albino rats of (Rattus novergicus Strain wistar), divided into 5 groups with six rats in each group. Group I comprises normal healthy rats remains untreated for 90 days;Group II comprises of high cholesterol diet induced atherosclerotic rats for 90 days; Group III, IV, and V comprise of high cholesterol diet induced atherosclerosis and were administered extract from pericarp of mangosteen orally (200mg/kg; 400 mg/kg, 800 mg/kg) daily for 90 days. After 90 days treatment, rats were decapitated and blood was sample collected from the aorta for determination level of TNF-α and IL-1 by ELISA. Aorta was taken to observe the expression of NF-kB, ICAM-1, and IL-6 using immunohistochemical techniques. Results. Oral administration (800 mg/kg) of the extract from pericarp of mangosteen significantly decreased the level of TNF-α, and IL-1 and also reduced the expression of NF-kB, ICAM-1, and IL-6. Conclusion. These results suggest that the extract from pericarp of mangosteen (Garcinia mangostana Linn)possess anti-inflammatory actions by reducing level of TNF-α, IL-1, and also reduce the expression of NF-kB, ICAM-1, and IL-6 that prevent the development of atherosclerosis.
| Item Type: | Article |
|---|---|
| Keywords: | Atherosclerosis, Garcinia mangostana Linn, anti-inflammatory, TNF-α, IL-1, IL-6, NF-kB, ICAM-1 |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RC Internal medicine |
| Divisions: | Faculty of Medicine > Department of Medicine (11201) |
| Depositing User: | Fathiyah Safithri |
| Date Deposited: | 05 Dec 2018 01:52 |
| Last Modified: | 05 Dec 2018 01:52 |
| URI : | http://eprints.umm.ac.id/id/eprint/41225 |
Actions (login required)
 |
View Item |
