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PENGARUH KOMBINASI EKSTRAK DAUN Mangifera indica L. DAN DAUN Syzygium polyanthum TERHADAP KADAR HDL PADA Rattus novergicus DIABETES

Nisa, Nadya Fachrun (2018) PENGARUH KOMBINASI EKSTRAK DAUN Mangifera indica L. DAN DAUN Syzygium polyanthum TERHADAP KADAR HDL PADA Rattus novergicus DIABETES. Undergraduate (S1) thesis, University of Muhammadiyah Malang.

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Abstract

Background : Diabetes Mellitus is a metabolic disorder characterized by the occurrence of insulin resistance. Insulin resistance results in abnormalities in fat metabolism. Insulin resistance can lead to increased levels of free fatty acids (FFA) because the hormone sensitive lipase (HSL) becomes active. FFA will be converted to triglyceride (TG) and become part of VLDL, then TG on VLDL will exchange with Cholesterol present in High Density Lipoprotein (HDL). This HDL will be easily catabolized in the kidneys. Herbal medicine are believed more safer than chemical medicine. Combination of Mangifera indica L. and Syzygium polyanthum ethanolic extract can be used as antidiabetic and antihyperlipidemic that can increased HDL levels in the body. Goal : The aim of this study was to determine the effect of combination ethanolic leaves extract of Mangifera indica L. and Syzygium polyanthum activity on HDL levels in diabetic Rattus norvegicus. Method : the study is used post only control group design method with using 36 Rattus norvegicus which is divided into 3 control groups (K(S), K(+), K(-)) and 3 treatment groups. Thin Layer Chromatograpgy also used in this research to identify the secondary metabolites of Mangifera indica L. dan Syzygium polyanthum ethanolic leaves extract. ABX Pentra HDL Direct CP method is used to measure of HDL levels. Then the data were analyzed by One Way Anova method using SPSS 21.0 edition. Result and Conclusion : Preliminary qualitative phytochemical screening using Thin Layer Chromatography reveals the presence of alkaloids, flavonoids terpenoids, tannins and antraquinones. From the results of this study, combinations of Mangifera indica L. and Syzygium polyanthum was able to increase HDL levels in Rattus norvegicus diabetes by comparison of dose variation (84 mg / 200gBB: 720 mg / 200gBB), (42 mg / 200gBB: 360 mg / 200gBB) (42 mg / 200gBB: 720 mg / 200gBB) although descriptively an increase in HDL levels does not reach normal levels. However, the highest increase in descriptive in comparison dose (82 mg / 200gBB: 360mg / 200gBB) with an average of 25.67 mg / dL although it did not reach normal levels.

Item Type: Thesis (Undergraduate (S1))
Student ID: 201410410311225
Keywords: HDL level, Diabetes Mellitus, Flavonoid, Mangifera indica L., Syzygium polyanthum
Subjects: R Medicine > RZ Other systems of medicine
Divisions: Faculty of Health Science > Department of Pharmacy (48201)
Depositing User: Nurhadin Nurhadin
Date Deposited: 28 Nov 2018 04:21
Last Modified: 28 Nov 2018 04:21
URI : http://eprints.umm.ac.id/id/eprint/41029

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