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PENGARUH KOMBINASI EKSTRAK ETANOL DAUN Mangifera indica L. var arumanis DAN PERASAN BUAH Abelmoschus esculentus L. Moench TERHADAP KADAR LDL PADA Rattus norvegicus DIABETES

Dewi, Fitriani Aulia (2018) PENGARUH KOMBINASI EKSTRAK ETANOL DAUN Mangifera indica L. var arumanis DAN PERASAN BUAH Abelmoschus esculentus L. Moench TERHADAP KADAR LDL PADA Rattus norvegicus DIABETES. Bachelors Degree (S1) thesis, University of Muhammadiyah Malang.

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Abstract

Background: Diabetes type 2 is a chronic hyperglicaemia disease which caused the occurence insulin resistance that increases LDL level. Conventional treatment with (multicomponent work-target) or involving multiple components proven can work synergistically. The combination of Mangifera indica L. var arumanis and Abelmoschus esculentus L. Moench have antidiabetic effects and decreasing LDL level. Goal: The research aims to know the effect of ethanol leaves extract Mangifera Indica var arumanis and squeezed fruit Abelmoschus esculentus L. Moench combination on effective dosage from that combination toward LDL level on Rattus norvegicus male induced diabetes. Method: This research uses post test only control group design by 24 Rattus norvegicus males divided in 6 groups, that are healthy control, negative control, positive control, and 3 treatment groups (P1, P2, and P3). Research is done for 30 days. LDL level is measured by using spectrophotometer semi-automatic analyzer with direct method. Obtained data is analyzed by using one way anova. Result and conclusion: The result shows that ethanol leaves extract Mangifera indica var arumanis by dosage 125 mg / kgBB, 250 mg / kgBB, and 500 mg / kgBB also combined by squeezed fruit Abelmoschus esculentus L. Moench 0,36ml/200g BB gives effect toward decreasing LDL level on diabetes mice. Effective dosage to decrease LDL level is in giving ethanol leaves extract Mangifera Indica var arumanis by dosage 500 mg / kgBB and squeezed fruit Abelmoschus esculentus L. Moench 0,36ml / 200g BB.

Item Type: Thesis (Bachelors Degree (S1))
Student ID: 201410410311029
Keywords: Mangifera indica L. var arumanis, Abelmoschus esculentus L. Moench, Diabetes, LDL
Subjects: R Medicine > RZ Other systems of medicine
Divisions: Faculty of Health Science > Department of Pharmacy (48201)
Depositing User: Nurhadin Nurhadin
Date Deposited: 23 Nov 2018 07:11
Last Modified: 23 Nov 2018 07:11
URI : http://eprints.umm.ac.id/id/eprint/40689

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