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PENGARUH FRAKSI KLOROFORMHERBA CIPLUKAN (Physalis Angulata L.) TERHADAP PENCEGAHAN KERUSAKAN FOTORESEPTOR TIKUS PUTIH (Rattus Norvegicus Strain Wistar) YANG DIINDUKSI STREPTOZOTOCIN

HASNA, ALIFAH (2018) PENGARUH FRAKSI KLOROFORMHERBA CIPLUKAN (Physalis Angulata L.) TERHADAP PENCEGAHAN KERUSAKAN FOTORESEPTOR TIKUS PUTIH (Rattus Norvegicus Strain Wistar) YANG DIINDUKSI STREPTOZOTOCIN. Undergraduate (S1) thesis, University of Muhammadiyah Malang.

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Abstract

Background: Diabetes mellitus (DM) according to the World Health Organization (WHO) in Indonesia will be ranked 5 in the world, complications of diabetes, namely Diabetic Retinopathy (DR) which becomes blindness. So, it was necessary the utilization of the fraction of chloroform herbs ciplukan (Physalis angulata L.), which contain unsaturated fatty acids, alkaloidnordextromethorphan and class of steroids that is aplysterylacetate effect of the antidiabetic stimulates insulin, is expected to prevent damage to the photoreceptors in diabetes mellitus with complications of diabetic retinopathy. Objective: To know the effectof chloroformfractionsciplukan herbs (Physalis angulata L.) toprevention damage photoreseptor white rat (Rattus Norvegicus Strain Wistar)was induced Streptozotocin. Method: True experimental with post test only control group design. The sample rats were divided into 5 groups: 1 control positive, 1 control negative and 3 treatment weregiven chloroform fractions of ciplukan herbsdose 0,91mg/200gramBW/day,1,82mg/200gramBW/day and 3,64mg/200gramBW/day. Result and Discussion: One way anova test showed difference (p=0,015), post hoc bonferoni test wasn't found significant differences (p>0,05) except for K+ with P2 (p<0,05). P2 with to 1.82 mg/200gramBB/day show a dose-effective with the result that thicker compared with the control negative and control positive. Conclusion:There's an effect of chloroform fractions of ciplukan herbs (Physalis angulata L.)to prevention damage photoreseptor white rat (Rattus Norvegicus Strain Wistar) was induced streptozotocin.

Item Type: Thesis (Undergraduate (S1))
Student ID: 201410330311030
Keywords: Photoreseptor, chloroform fraction of ciplukan herbs.
Subjects: R Medicine > R Medicine (General)
Divisions: Faculty of Medicine > Department of Medicine (11201)
Depositing User: Nurhadin Nurhadin
Date Deposited: 09 Nov 2018 07:02
Last Modified: 09 Nov 2018 07:02
URI : http://eprints.umm.ac.id/id/eprint/39732

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