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The Effect of Acrylamide on Steeping Robusta Coffee (Coffea canephora var. Robusta) to Memory Function and Histopathological Changes of Brain Cells in Male Rats (Rattus Novergicus)

Lestari, Dian Yuliartha and Bahrudin, Muhammad and Rahayu, Rahayu and Fadhil, Fadhil and Avisa, Avisa (2017) The Effect of Acrylamide on Steeping Robusta Coffee (Coffea canephora var. Robusta) to Memory Function and Histopathological Changes of Brain Cells in Male Rats (Rattus Novergicus). In: Advances in Biomolecular Medicine: Proceedings of the 4th BIBMC (Bandung International Biomolecular Medicine Conference) 2016 and the 2nd ACMM (ASEAN Congress on Medical Biotechnology and Molecular Biosciences) October 4-6 2016 Bandung West Java Indonesia. CRC Press Taylor & Francis Group, London, pp. 33-36. ISBN 9781138631779

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Abstract

ABSTRACT: Coffee is known to contain acrylamide carcinogenic that will lead to changes in the chemical structure of DNA, resulting in the degeneration of brain cells and contains caffeine, melanoidin, chlorogenic acid, flavonoids that are predicted could improve memory function. Objective. To evaluate the effect of steeping robusta coffee (Coffea canephoravar.Robusta) to improved memory function in male rats (Rattus novergicus) with Morris Water Maze test method and histopathological changes in brain cells. Methods. True experiment, the post test only control group design. The samples were divided into 5 groups. Group 1: normal control; group II,III,IV,V was given with steeping robusta coffee (Coffea canephoravar.Robusta) at the doses (0,36 ml, 0,72 ml, 1,44 ml, 2,16 ml) with Morris Water Maze test for 28 days. Result. For memory function, one way ANOVA test showed significant effect (sig = 0,000 < p(0,05)). Tukey test obtained significant value of p (> 0.05) in the group treated with a dose of (0,36 ml, 0,72 ml, 1,44 ml, 2,16 ml) had a significant difference to the normal control while the dose groups 0,36 ml no significant difference to the negative control. Pearson correlation test obtained value of 0.953, which means that higher dose given steeping robusta coffee, the higher time required to find a hidden platform. For histopathological changes, one Way ANOVA test showed p (<0,05), which means there is a significant effect. Tukey test obtained significant value of p (>0,05) in the group treated. The strength of the relation shows the effect of Robusta coffee steeping 92,2% of the increasing number of edema cells in the brain. Conclusion. Steeping Robusta coffee can cause decrease of memory function and brain histopathological changes in male rats.

Item Type: Book Section
Uncontrolled Keywords: Acrylamide, coffee robusta, memory function, brain cells
Subjects: R Medicine > RB Pathology
Divisions: Faculty of Medicine > Department of Medical Education
Depositing User: dr Dian Yuliartha Lestari
Date Deposited: 01 Sep 2018 02:09
Last Modified: 07 Sep 2018 02:14
URI : http://eprints.umm.ac.id/id/eprint/37356

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