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PENGARUH KADAR PVP K-30 TERHADAP MUTU FISIK TABLET HISAP EKSTRAK DAUN SIRIH (Piper betle L) DENGAN BASIS SUKROSA (GULA BATU)

Arti, Sopha Dwi (2013) PENGARUH KADAR PVP K-30 TERHADAP MUTU FISIK TABLET HISAP EKSTRAK DAUN SIRIH (Piper betle L) DENGAN BASIS SUKROSA (GULA BATU). Other thesis, University of Muhammadiyah Malang.

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Abstract

Piper betle L. leaves is a traditional medicine as an antibacterial, it is caused by the presence of essential oil that contained phenolic compound and their derivatives which have an active ingredient kavikol. Its usually used in a stew that is considered less practical, so it needs to be made practical preparations be lozenges. The purpose of this study was to determine the effect of PVP K-30 as a tablet binder to the physical quality of Piper betle L. leaf extract lozenges and determine the lozenges with the best physical quality that meet the requirements. Preparation of Piper betle L. leaf extract lozenges was done by direct press method. Basic granul used in the preparation was sucrose which using binding agents with different concentration. There was PVP K-30 1.0%, 2.0% and 3.0% concentration. The granules were compressed with hydraulic press at 2 ton pressure. Physical quality of Piper betle L. leaf extract lezenges has been evaluated, including hardness, friability and disintegrating time. Analyzed using one way anova showed a significant difference in physical quality of each tablet formulaÂ’s to elevated concentration of PVP K-30 unless the precentage of friability. It can be concluded that the higher concentration of PVP K-30 will increasing the hardness and disintegration time but no impact to the friability of lozenges and the basic granules sucrose using PVP K-30 1.0% was chosen formula for Piper betle L. leaf extract lozenges. Key words: Piper betle L. Extract, PVP K-30, Sucrose, Lozenges.

Item Type: Thesis (Other)
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Health Science > Department of Pharmacy (48201)
Depositing User: Mr Moch. sholeh
Date Deposited: 10 May 2016 03:15
Last Modified: 10 May 2016 03:15
URI : http://eprints.umm.ac.id/id/eprint/29380

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