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MODIFIKASI STRUKTUR SALISILAMIDA MENJADI N-HEKSANOIL SALISILAMIDA

YULIANTI, FIRDHA ANITA (2013) MODIFIKASI STRUKTUR SALISILAMIDA MENJADI N-HEKSANOIL SALISILAMIDA. Other thesis, University of Muhammadiyah Malang.

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Abstract

Salicylamide is one of NSAID class that have weak therapeutic effect of analgesic and antipyretic. Therefore, a novel Salicylamide derivative was synthesized by modified Schotten-BaumannÂ’s method on asilation reaction. Reaction between Salicylamide and Hexanoyl chloride for 2 hours to produce N-Hexanoyl Salicylamide. Target compound purified by recrystalisation. The purity was identified using Thin Layer Chromatography (TLC) & melting point test. The yield percentage of target compound was 0,68%. Purified compound characterized and identified by spectrometer 1HNMR, spectrofotometer FTIR KBr and UV. Product compound form white crystal with melting range about 134-135oC. Spectra of 1HNMR and FTIR KBr showed that pure N-Hexanoyl Salicylamide was successfully synthesized. Keyword: Salicylamide, N-Heksanoyl Salicylamide, Schotten-Baumann

Item Type: Thesis (Other)
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Health Science > Department of Pharmacy (48201)
Depositing User: Mr Moch. sholeh
Date Deposited: 27 Apr 2016 07:57
Last Modified: 27 Apr 2016 07:57
URI : http://eprints.umm.ac.id/id/eprint/28351

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