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PREPARASI SENYAWA O-(4-METOKSIBENZOIL) PARASETAMOL DAN UJI AKTIVITAS ANALGESIK PADA MENCIT (Mus musculus)

FRANSISKA, EKA PUTRI EMILIA AGUSTINA (2013) PREPARASI SENYAWA O-(4-METOKSIBENZOIL) PARASETAMOL DAN UJI AKTIVITAS ANALGESIK PADA MENCIT (Mus musculus). Other thesis, University of Muhammadiyah Malang.

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Abstract

According to development the new drug of NSAID group, preparation of O-(4-methoxybenzoyl) paracetamol had been done by reaction of paracetamol and 4-methoxybenzoyl chloride, based on Schotten-Baumann method. The yield of the compound preparation of O-(4-methoxybenzoyl) paracetamol was 52% with organoleptic powder, white and no smell, and its melting point was 160-1630C, with Rf 0.76 on a non-polar movement phase. The compound was identified by using the spectrophotometric data of ultra-violet, infra-red and also the 1H-nuclear magnetic resonance spectrometric. The analgesic activity was tested using the writhing test method. That is done by comparing the activity of a group of test compound O-(4-metoksibenzoil) paracetamol with the standart compound paracetamol, with each dose of 25, 50, and 100 mg/kg mice body weight, which then can be viewed the pain inhibition percentage so that the results obtained calculation of ED50 was around 30.92 mg/kg mice body weight, whereas the comparison group showed paracetamol ED50 was around 67.78 mg/Kg mice body weight. The result from the analgesic activity test for this new compound shows that this new compound O-(4-methoxybenzoyl) paracetamol has better analgesic activity than paracetamol. Keyword : preparation, analgesic activity test, O-(4-methoxybenzoyl) paracetamol, mice.

Item Type: Thesis (Other)
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Health Science > Department of Pharmacy (48201)
Depositing User: Mr Moch. sholeh
Date Deposited: 26 Apr 2016 03:13
Last Modified: 26 Apr 2016 03:13
URI : http://eprints.umm.ac.id/id/eprint/28161

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