Unfolding Biomechanism of Dolichos lablab Bean as A Dietary Supplement in Type 2 Diabetes Mellitus Management through Computational Simulation

Purwanti, Elly and Hermanto, Feri and Prihanta, Wahyu (2022) Unfolding Biomechanism of Dolichos lablab Bean as A Dietary Supplement in Type 2 Diabetes Mellitus Management through Computational Simulation. Research Journal of Pharmacy and Technology (RJPT), 15 (7). pp. 860-871. ISSN 0974-360X

[thumbnail of Purwanti Hermanti Prihanta Permana - Unfolding Biomechanism of Dolichos.pdf]
Preview
Text
Purwanti Hermanti Prihanta Permana - Unfolding Biomechanism of Dolichos.pdf

Download (9MB) | Preview
[thumbnail of Similarity - Purwanti Hermanti Prihanta Permana - Unfolding Biomechanism of Dolichos.pdf]
Preview
Text
Similarity - Purwanti Hermanti Prihanta Permana - Unfolding Biomechanism of Dolichos.pdf

Download (13MB) | Preview

Abstract

Dietary intervention, particularly legumes consumption, plays a significant role in promoting health status in
diabetes mellitus management. As poorly known legumes, Dolichos lablab (DL) is possibly to be one of the
dietary options for diabetes intervention. However, the predictive or precise mechanism of DL’s anti -diabetic
activity remains inconclusive. This study aimed to determine the nutritional and phytochemical content in
addition to anti-diabetic properties of DL. Total protein, crude fat, crude fibers, and gross energy were evaluated,
while anti-diabetic properties were predicted using molecular docking according to identified compound from
Liquid Chromatography-High Resolution Mass Spectrometry (LC-HRMS) analysis. Screened compound from
molecular docking then passed to physicochemical properties and bioactivity prediction using Swiss-ADME and
molinspiration, separately. The result showed that DL has high protein fiber and gross energy content with a
lower fat percentage. Additionally, DL has numerous phenolic acid and flavonoid compounds according to LCHRMS

analysis. From the docking analysis, fourteen compounds have substantial probability to give the
beneficial effect of glucose metabolism regulator and insulin signaling repairers through inhibition of ɑ-amylase,
DPP4, and PTP1B. Finally, from the physicochemical properties and bioactivity estimations, 19Norandrostenedione,

19-Nortestosterone, Icariside B1, Ilicic Acid, and Psilostachyin B have excellent
pharmacokinetic properties along with considerable biological activity as enzyme inhibitors and nuclear receptor
ligands. In conclusion, nutritional evaluation and molecular docking analysis revealed that DL might serve as a
suitable dietary intervention for diabetes mellitus management.

Item Type: Article
Keywords: ɑ-Amylase, Dolichos lablab, Diabetes mellitus, DPP4, PTP1B
Subjects: L Education > L Education (General)
Q Science > Q Science (General)
Divisions: Faculty of Teacher Training and Education > Department of Biology Education (84205)
Depositing User: wahyuprihanta Wahyu Prihanta, Drs., M.Kes.
Date Deposited: 19 Jan 2024 05:56
Last Modified: 19 Jan 2024 05:56
URI: https://eprints.umm.ac.id/id/eprint/2650

Actions (login required)

View Item
View Item